Drug interactions
Fosaprepitant + Ranolazine
Severity: Moderate
Fosaprepitant and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a moderate and transient CYP3A4 inhibitor after a single dose. It may modestly increase ranolazine exposure, though this is usually limited.
What this interaction means in plain words
Fosaprepitant and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Ranolazine belongs to Cardiovascular.
Why it happens
Weak to moderate, short-lived CYP3A4 inhibition by aprepitant.
What to do
Monitor for ranolazine adverse effects such as dizziness, nausea and QT prolongation around the dose. Limit ranolazine to a lower dose if multiple doses are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Ranolazine?
MediHelp rates the interaction as moderate. Fosaprepitant and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, via aprepitant, is a moderate and transient CYP3A4 inhibitor after a single dose. It may modestly increase ranolazine exposure, though this is usually limited.
How serious is the interaction between Fosaprepitant and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ranolazine adverse effects such as dizziness, nausea and QT prolongation around the dose. Limit ranolazine to a lower dose if multiple doses are given.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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