Drug interactions
Fosaprepitant + Ruxolitinib
Severity: Minor
Fosaprepitant and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, via aprepitant, is a weak-to-moderate CYP3A4 inhibitor and may modestly increase ruxolitinib exposure with single-dose use. Any effect is typically transient and small.
What this interaction means in plain words
Fosaprepitant and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Ruxolitinib belongs to Oncology.
Why it happens
Aprepitant, the active form of fosaprepitant, transiently inhibits CYP3A4 metabolism of ruxolitinib.
What to do
No dose adjustment is usually needed; monitor blood counts as per routine ruxolitinib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ruxolitinib
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Ruxolitinib?
MediHelp rates the interaction as minor. Fosaprepitant and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, via aprepitant, is a weak-to-moderate CYP3A4 inhibitor and may modestly increase ruxolitinib exposure with single-dose use. Any effect is typically transient and small.
How serious is the interaction between Fosaprepitant and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood counts as per routine ruxolitinib care.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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