Drug interactions
Fosaprepitant + Trazodone
Severity: Moderate
Fosaprepitant and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and may increase trazodone concentrations after single-dose use. Effects could include increased sedation and hypotension, although the effect is usually modest and short-lived.
What this interaction means in plain words
Fosaprepitant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosaprepitant belongs to Gastrointestinal Tract; Trazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism.
What to do
Monitor for increased sedation and hypotension for several days after fosaprepitant and consider a trazodone dose reduction if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Trazodone?
MediHelp rates the interaction as moderate. Fosaprepitant and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor and may increase trazodone concentrations after single-dose use. Effects could include increased sedation and hypotension, although the effect is usually modest and short-lived.
How serious is the interaction between Fosaprepitant and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and hypotension for several days after fosaprepitant and consider a trazodone dose reduction if symptoms occur.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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