Drug interactions
Fosaprepitant + Zonisamide
Severity: Minor
Fosaprepitant and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, through aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose and could slightly raise zonisamide levels for a few days. The effect is short-lived and unlikely to matter in most patients.
What this interaction means in plain words
Fosaprepitant and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Zonisamide belongs to Central Nervous System.
Why it happens
Temporary CYP3A4 inhibition by aprepitant reduces zonisamide metabolism.
What to do
No dose change is usually needed. Watch for increased drowsiness in the days after the dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Zonisamide?
MediHelp rates the interaction as minor. Fosaprepitant and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, through aprepitant, is a weak-to-moderate CYP3A4 inhibitor after a single dose and could slightly raise zonisamide levels for a few days. The effect is short-lived and unlikely to matter in most patients.
How serious is the interaction between Fosaprepitant and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for increased drowsiness in the days after the dose.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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