Drug interactions
Fosinopril + Icatibant
Severity: Minor
Fosinopril and Icatibant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks the bradykinin B2 receptor, part of the ACE inhibitor effect pathway. It may attenuate some ACE inhibitor effects, which is of uncertain clinical relevance during short-term treatment of angioedema attacks.
What this interaction means in plain words
Fosinopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosinopril belongs to Cardiovascular; Icatibant belongs to Miscellaneous.
Why it happens
Bradykinin B2 receptor antagonism may theoretically reduce bradykinin-mediated components of ACE inhibitor action.
What to do
Monitor blood pressure after icatibant use; no routine dose changes are needed. Note that ACE inhibitor-induced angioedema requires stopping fosinopril.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Fosinopril with Icatibant?
MediHelp rates the interaction as minor. Fosinopril and Icatibant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks the bradykinin B2 receptor, part of the ACE inhibitor effect pathway. It may attenuate some ACE inhibitor effects, which is of uncertain clinical relevance during short-term treatment of angioedema attacks.
How serious is the interaction between Fosinopril and Icatibant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after icatibant use; no routine dose changes are needed. Note that ACE inhibitor-induced angioedema requires stopping fosinopril.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
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