Drug interactions
Fosinopril-hydrochlorothiazide + Toremifene
Severity: Moderate
Fosinopril-hydrochlorothiazide and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia, especially in patients with bone metastases, and thiazides reduce urinary calcium excretion. The combination may therefore raise serum calcium, and toremifene labeling advises caution with thiazides.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-reduced renal calcium excretion adds to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium early in therapy and periodically; consider an alternative antihypertensive if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Toremifene?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia, especially in patients with bone metastases, and thiazides reduce urinary calcium excretion. The combination may therefore raise serum calcium, and toremifene labeling advises caution with thiazides.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium early in therapy and periodically; consider an alternative antihypertensive if hypercalcemia develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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