Drug interactions
Fostamatinib + Itraconazole
Severity: Moderate
Fostamatinib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases exposure to R406, the active metabolite of fostamatinib. This may increase dose-related adverse effects including hypertension, diarrhea, hepatotoxicity and neutropenia.
What this interaction means in plain words
Fostamatinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces metabolism of R406.
What to do
Monitor blood pressure, liver enzymes and neutrophil counts. Reduce or interrupt fostamatinib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Itraconazole?
MediHelp rates the interaction as moderate. Fostamatinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole increases exposure to R406, the active metabolite of fostamatinib. This may increase dose-related adverse effects including hypertension, diarrhea, hepatotoxicity and neutropenia.
How serious is the interaction between Fostamatinib and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver enzymes and neutrophil counts. Reduce or interrupt fostamatinib if toxicity develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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