Drug interactions
Fostamatinib + Ribociclib
Severity: Moderate
Fostamatinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 is metabolized by CYP3A4. Ribociclib may increase R406 exposure, potentially worsening hypertension, diarrhea, hepatotoxicity and neutropenia.
What this interaction means in plain words
Fostamatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing clearance of fostamatinib's active metabolite R406.
What to do
Monitor blood pressure, liver enzymes and neutrophil count. Reduce the fostamatinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Ribociclib?
MediHelp rates the interaction as moderate. Fostamatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite R406 is metabolized by CYP3A4. Ribociclib may increase R406 exposure, potentially worsening hypertension, diarrhea, hepatotoxicity and neutropenia.
How serious is the interaction between Fostamatinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver enzymes and neutrophil count. Reduce the fostamatinib dose if adverse effects occur.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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