Drug interactions
Fostamatinib + Rimegepant
Severity: Moderate
Fostamatinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may raise rimegepant exposure. Adverse effects may be more likely.
What this interaction means in plain words
Fostamatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux increases rimegepant exposure.
What to do
Avoid a second rimegepant dose within 48 hours of the first. Monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Rimegepant?
MediHelp rates the interaction as moderate. Fostamatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits P-glycoprotein and may raise rimegepant exposure. Adverse effects may be more likely.
How serious is the interaction between Fostamatinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours of the first. Monitor tolerability.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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