Drug interactions
Fostemsavir + Leuprolide
Severity: Moderate
Fostemsavir and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QTc prolongation at supratherapeutic doses, while leuprolide may also lengthen the QT interval. The combination may modestly increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Fostemsavir and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use recommended fostemsavir doses and obtain an ECG in patients with cardiac risk factors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Leuprolide?
MediHelp rates the interaction as moderate. Fostemsavir and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QTc prolongation at supratherapeutic doses, while leuprolide may also lengthen the QT interval. The combination may modestly increase arrhythmia risk in susceptible patients.
How serious is the interaction between Fostemsavir and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use recommended fostemsavir doses and obtain an ECG in patients with cardiac risk factors. Correct electrolyte abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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