Drug interactions
Fostemsavir + Propofol
Severity: Minor
Fostemsavir and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir at supratherapeutic doses has been associated with QTc prolongation, and propofol has been rarely associated with QT effects and arrhythmias. At recommended fostemsavir doses the clinical risk is low, though caution is reasonable in patients with other QT risk factors.
What this interaction means in plain words
Fostemsavir and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostemsavir belongs to Anti Virals; Propofol belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; fostemsavir effect is mainly seen at supratherapeutic exposures.
What to do
Check ECG and correct electrolytes in patients with additional QT risk factors, and monitor ECG during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Propofol?
MediHelp rates the interaction as minor. Fostemsavir and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostemsavir at supratherapeutic doses has been associated with QTc prolongation, and propofol has been rarely associated with QT effects and arrhythmias. At recommended fostemsavir doses the clinical risk is low, though caution is reasonable in patients with other QT risk factors.
How serious is the interaction between Fostemsavir and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct electrolytes in patients with additional QT risk factors, and monitor ECG during anesthesia.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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