Drug interactions
Furosemide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Furosemide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide adds to the diuretic effect of hydrochlorothiazide and irbesartan, which can cause hypotension, volume depletion, electrolyte loss and acute kidney function decline, especially when starting an ARB in a patient on a loop diuretic. Furosemide-induced hypokalemia is partly offset by irbesartan, but hyponatremia and hypomagnesemia can still occur.
What this interaction means in plain words
Furosemide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Sequential nephron blockade with loop and thiazide diuretics combined with RAAS inhibition produces additive natriuresis and reduced glomerular filtration pressure.
What to do
Monitor blood pressure, weight, serum sodium, potassium and creatinine after starting or adjusting therapy. Reduce the diuretic dose if volume depletion or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Furosemide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide adds to the diuretic effect of hydrochlorothiazide and irbesartan, which can cause hypotension, volume depletion, electrolyte loss and acute kidney function decline, especially when starting an ARB in a patient on a loop diuretic. Furosemide-induced hypokalemia is partly offset by irbesartan, but hyponatremia and hypomagnesemia can still occur.
How serious is the interaction between Furosemide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, serum sodium, potassium and creatinine after starting or adjusting therapy. Reduce the diuretic dose if volume depletion or hypotension develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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