Drug interactions
Furosemide + Insulin degludec-insulin aspart
Severity: Moderate
Furosemide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise blood glucose and impair glucose tolerance, which may reduce the effect of insulin. Higher insulin doses may be needed in some patients.
What this interaction means in plain words
Furosemide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Diuretic-induced potassium depletion may impair insulin secretion and sensitivity, antagonizing insulin.
What to do
Monitor blood glucose and serum potassium when furosemide is started or the dose changed. Adjust the insulin dose and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Furosemide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise blood glucose and impair glucose tolerance, which may reduce the effect of insulin. Higher insulin doses may be needed in some patients.
How serious is the interaction between Furosemide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when furosemide is started or the dose changed. Adjust the insulin dose and correct hypokalemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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