Drug interactions
Furosemide + Paromomycin
Severity: Moderate
Furosemide and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is an aminoglycoside that is minimally absorbed orally, but absorption may increase with intestinal ulceration or renal impairment. Together with a loop diuretic this could add to ototoxic and nephrotoxic risk.
What this interaction means in plain words
Furosemide and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Paromomycin belongs to Anti Bacterial.
Why it happens
Potential additive ototoxicity and nephrotoxicity if systemic aminoglycoside absorption occurs.
What to do
Monitor renal function and auditory symptoms in patients with renal impairment or GI mucosal damage, and consider an alternative to the loop diuretic or antiparasitic where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Paromomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Furosemide with Paromomycin?
MediHelp rates the interaction as moderate. Furosemide and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paromomycin is an aminoglycoside that is minimally absorbed orally, but absorption may increase with intestinal ulceration or renal impairment. Together with a loop diuretic this could add to ototoxic and nephrotoxic risk.
How serious is the interaction between Furosemide and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and auditory symptoms in patients with renal impairment or GI mucosal damage, and consider an alternative to the loop diuretic or antiparasitic where feasible.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
