Drug interactions
Furosemide + Penicillin g
Severity: Minor
Furosemide and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide competes with penicillin G for renal tubular secretion through organic anion transporters, which may modestly slow penicillin elimination. Serum penicillin levels may rise slightly, which is rarely of clinical importance at usual doses.
What this interaction means in plain words
Furosemide and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; Penicillin g belongs to Anti Bacterial.
Why it happens
Competition for organic anion transporter-mediated tubular secretion reduces penicillin G clearance.
What to do
No routine adjustment needed; watch for neurotoxicity in renal impairment on high-dose penicillin G.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Penicillin g?
MediHelp rates the interaction as minor. Furosemide and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide competes with penicillin G for renal tubular secretion through organic anion transporters, which may modestly slow penicillin elimination. Serum penicillin levels may rise slightly, which is rarely of clinical importance at usual doses.
How serious is the interaction between Furosemide and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; watch for neurotoxicity in renal impairment on high-dose penicillin G.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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