Drug interactions
Furosemide + Pretomanid
Severity: Minor
Furosemide and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits the renal organic anion transporter 3 in vitro, and furosemide is a substrate of this transporter. Reduced tubular secretion could raise furosemide exposure, although the net effect on diuresis has not been clinically characterised.
What this interaction means in plain words
Furosemide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of furosemide by pretomanid.
What to do
Monitor diuretic response, blood pressure, renal function and electrolytes when starting pretomanid. Reduce the furosemide dose if signs of excessive effect appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Furosemide with Pretomanid?
MediHelp rates the interaction as minor. Furosemide and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits the renal organic anion transporter 3 in vitro, and furosemide is a substrate of this transporter. Reduced tubular secretion could raise furosemide exposure, although the net effect on diuresis has not been clinically characterised.
How serious is the interaction between Furosemide and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, blood pressure, renal function and electrolytes when starting pretomanid. Reduce the furosemide dose if signs of excessive effect appear.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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