Drug interactions
Furosemide + Tiotropium-olodaterol
Severity: Moderate
Furosemide and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide causes renal potassium loss and olodaterol can shift potassium into cells. The combination can produce hypokalemia that may promote arrhythmias.
What this interaction means in plain words
Furosemide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive lowering of serum potassium via diuretic-induced loss and beta2-mediated intracellular shift.
What to do
Monitor serum potassium and magnesium, and supplement as needed. Take particular care in patients taking digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Furosemide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide causes renal potassium loss and olodaterol can shift potassium into cells. The combination can produce hypokalemia that may promote arrhythmias.
How serious is the interaction between Furosemide and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, and supplement as needed. Take particular care in patients taking digoxin.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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