Drug interactions
Furosemide + Vadadustat
Severity: Moderate
Furosemide and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3, a transporter involved in renal secretion of furosemide, and can increase furosemide exposure. This may enhance diuresis and its adverse effects such as volume depletion and electrolyte disturbance.
What this interaction means in plain words
Furosemide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of furosemide.
What to do
Monitor volume status, blood pressure, electrolytes and renal function. Reduce the furosemide dose if exaggerated diuresis occurs, as advised in the vadadustat labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Furosemide with Vadadustat?
MediHelp rates the interaction as moderate. Furosemide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits OAT3, a transporter involved in renal secretion of furosemide, and can increase furosemide exposure. This may enhance diuresis and its adverse effects such as volume depletion and electrolyte disturbance.
How serious is the interaction between Furosemide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure, electrolytes and renal function. Reduce the furosemide dose if exaggerated diuresis occurs, as advised in the vadadustat labeling.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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