Drug interactions
Gabapentin enacarbil + Metoclopramide
Severity: Minor
Gabapentin enacarbil and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS effects such as drowsiness, dizziness and fatigue. Used together, sedation and impaired psychomotor performance may be more pronounced, and metoclopramide can add to extrapyramidal or mood-related adverse effects.
What this interaction means in plain words
Gabapentin enacarbil and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin enacarbil belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depressant effects; no pharmacokinetic interaction is established.
What to do
Counsel patients about additive drowsiness and advise caution with driving or machinery. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Metoclopramide?
MediHelp rates the interaction as minor. Gabapentin enacarbil and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause CNS effects such as drowsiness, dizziness and fatigue. Used together, sedation and impaired psychomotor performance may be more pronounced, and metoclopramide can add to extrapyramidal or mood-related adverse effects.
How serious is the interaction between Gabapentin enacarbil and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and advise caution with driving or machinery. Reduce doses if excessive sedation occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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