Drug interactions
Gabapentin enacarbil + Vilazodone
Severity: Moderate
Gabapentin enacarbil and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil causes sedation and dizziness, and vilazodone can also cause somnolence and dizziness. Used together, central nervous system depression may be greater, with impaired alertness and psychomotor performance. Respiratory depression is mainly a concern in patients with respiratory risk factors or other sedatives on board.
What this interaction means in plain words
Gabapentin enacarbil and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor for excessive sedation and, in patients with respiratory risk, for respiratory depression. Advise patients to avoid driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Vilazodone?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil causes sedation and dizziness, and vilazodone can also cause somnolence and dizziness. Used together, central nervous system depression may be greater, with impaired alertness and psychomotor performance. Respiratory depression is mainly a concern in patients with respiratory risk factors or other sedatives on board.
How serious is the interaction between Gabapentin enacarbil and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and, in patients with respiratory risk, for respiratory depression. Advise patients to avoid driving until the combined effect is known.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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