Drug interactions
Gefitinib + Posaconazole
Severity: Moderate
Gefitinib and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises gefitinib exposure, which may increase adverse effects such as diarrhea, rash and liver enzyme elevations.
What this interaction means in plain words
Gefitinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces gefitinib metabolism and increases its concentrations.
What to do
Monitor for gefitinib toxicity, including diarrhea, skin reactions and hepatic function. Interrupt or adjust gefitinib if adverse effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Posaconazole?
MediHelp rates the interaction as moderate. Gefitinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises gefitinib exposure, which may increase adverse effects such as diarrhea, rash and liver enzyme elevations.
How serious is the interaction between Gefitinib and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gefitinib toxicity, including diarrhea, skin reactions and hepatic function. Interrupt or adjust gefitinib if adverse effects become significant.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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