Drug interactions
Gemfibrozil + Insulin glargine
Severity: Minor
Gemfibrozil and Insulin glargine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may slightly potentiate the glucose-lowering effect of insulin glargine, raising the chance of hypoglycemia in some patients. The effect is usually small.
What this interaction means in plain words
Gemfibrozil and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gemfibrozil belongs to Cardiovascular; Insulin glargine belongs to Endocrine.
Why it happens
Additive glucose lowering, possibly through improved insulin sensitivity; no pharmacokinetic mechanism is established.
What to do
Monitor blood glucose after starting or stopping gemfibrozil. Lower the glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Insulin glargine
Frequently asked questions
Can I take Gemfibrozil with Insulin glargine?
MediHelp rates the interaction as minor. Gemfibrozil and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil may slightly potentiate the glucose-lowering effect of insulin glargine, raising the chance of hypoglycemia in some patients. The effect is usually small.
How serious is the interaction between Gemfibrozil and Insulin glargine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping gemfibrozil. Lower the glargine dose if hypoglycemia occurs.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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