Drug interactions
Gemfibrozil + Letermovir
Severity: Moderate
Gemfibrozil and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase letermovir concentrations by blocking its hepatic uptake. Higher exposure could increase letermovir adverse effects such as gastrointestinal upset.
What this interaction means in plain words
Gemfibrozil and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1/3-mediated hepatic uptake of letermovir.
What to do
Monitor for letermovir adverse effects; consider an alternative lipid-lowering agent if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Gemfibrozil with Letermovir?
MediHelp rates the interaction as moderate. Gemfibrozil and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase letermovir concentrations by blocking its hepatic uptake. Higher exposure could increase letermovir adverse effects such as gastrointestinal upset.
How serious is the interaction between Gemfibrozil and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for letermovir adverse effects; consider an alternative lipid-lowering agent if tolerability problems arise.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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