Drug interactions
Gemfibrozil + Ospemifene
Severity: Moderate
Gemfibrozil and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase ospemifene exposure through inhibition of its oxidative metabolism. Higher levels could increase estrogen-agonist risks such as endometrial effects and thromboembolism.
What this interaction means in plain words
Gemfibrozil and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Ospemifene belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 and CYP2C19 metabolism of ospemifene, predicted from gemfibrozil's inhibitory properties.
What to do
Monitor for ospemifene adverse effects, including vaginal bleeding and thromboembolic symptoms; consider a different lipid-lowering agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Gemfibrozil with Ospemifene?
MediHelp rates the interaction as moderate. Gemfibrozil and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase ospemifene exposure through inhibition of its oxidative metabolism. Higher levels could increase estrogen-agonist risks such as endometrial effects and thromboembolism.
How serious is the interaction between Gemfibrozil and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects, including vaginal bleeding and thromboembolic symptoms; consider a different lipid-lowering agent.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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