Drug interactions
Gemfibrozil + Revefenacin
Severity: Moderate
Gemfibrozil and Revefenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Revefenacin's active metabolite is a substrate of OATP1B1 and OATP1B3, and gemfibrozil inhibits OATP1B1. Systemic exposure to the metabolite may rise, increasing anticholinergic effects such as dry mouth, urinary retention and tachycardia.
What this interaction means in plain words
Gemfibrozil and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Revefenacin belongs to Respiratory.
Why it happens
Gemfibrozil inhibits OATP-mediated hepatic uptake of the active metabolite of revefenacin.
What to do
Labeling does not recommend coadministration with OATP1B1/1B3 inhibitors. Consider an alternative lipid-lowering agent or bronchodilator and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Gemfibrozil with Revefenacin?
MediHelp rates the interaction as moderate. Gemfibrozil and Revefenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Revefenacin's active metabolite is a substrate of OATP1B1 and OATP1B3, and gemfibrozil inhibits OATP1B1. Systemic exposure to the metabolite may rise, increasing anticholinergic effects such as dry mouth, urinary retention and tachycardia.
How serious is the interaction between Gemfibrozil and Revefenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling does not recommend coadministration with OATP1B1/1B3 inhibitors. Consider an alternative lipid-lowering agent or bronchodilator and monitor for anticholinergic effects.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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