Drug interactions
Gemfibrozil + Rosiglitazone
Severity: Moderate
Gemfibrozil and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil raises rosiglitazone concentrations by inhibiting its metabolism. Higher exposure may increase fluid retention, edema and hypoglycemia risk.
What this interaction means in plain words
Gemfibrozil and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Gemfibrozil and its glucuronide inhibit CYP2C8, the main enzyme metabolizing rosiglitazone.
What to do
Monitor blood glucose and for edema or heart failure signs, and reduce the rosiglitazone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Gemfibrozil with Rosiglitazone?
MediHelp rates the interaction as moderate. Gemfibrozil and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil raises rosiglitazone concentrations by inhibiting its metabolism. Higher exposure may increase fluid retention, edema and hypoglycemia risk.
How serious is the interaction between Gemfibrozil and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for edema or heart failure signs, and reduce the rosiglitazone dose if needed.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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