Drug interactions
Gemifloxacin + Lenvatinib
Severity: Moderate
Gemifloxacin and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and lenvatinib labeling recommends close ECG monitoring with other QT-prolonging drugs. The combination can increase the risk of torsades de pointes, especially with electrolyte disturbances.
What this interaction means in plain words
Gemifloxacin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Lenvatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and keep potassium, magnesium and calcium within normal range. Prefer a non-QT-prolonging antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Gemifloxacin with Lenvatinib?
MediHelp rates the interaction as moderate. Gemifloxacin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and lenvatinib labeling recommends close ECG monitoring with other QT-prolonging drugs. The combination can increase the risk of torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Gemifloxacin and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium, magnesium and calcium within normal range. Prefer a non-QT-prolonging antibiotic if possible.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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