Drug interactions
Gemifloxacin + Midostaurin
Severity: Major
Gemifloxacin and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin has been associated with QT prolongation and gemifloxacin has the same liability. Combined use may increase the risk of significant QTc prolongation and arrhythmia.
What this interaction means in plain words
Gemifloxacin and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemifloxacin belongs to Anti Bacterial; Midostaurin belongs to Oncology.
Why it happens
Additive delayed ventricular repolarization.
What to do
Use an alternative antibiotic when possible. If both are required, monitor ECG and electrolytes at baseline and periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gemifloxacin and Midostaurin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Gemifloxacin with Midostaurin?
MediHelp rates the interaction as major. Gemifloxacin and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin has been associated with QT prolongation and gemifloxacin has the same liability. Combined use may increase the risk of significant QTc prolongation and arrhythmia.
How serious is the interaction between Gemifloxacin and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when possible. If both are required, monitor ECG and electrolytes at baseline and periodically.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
