Drug interactions
Gemifloxacin + Ranolazine
Severity: Moderate
Gemifloxacin and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine causes dose-related QT prolongation, and gemifloxacin can add to this effect. The combination may raise the risk of ventricular arrhythmia, especially in patients with structural heart disease.
What this interaction means in plain words
Gemifloxacin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation; ranolazine inhibits the delayed rectifier potassium current.
What to do
Obtain a baseline ECG and monitor the QTc during the antibiotic course. Choose a non-QT-prolonging antibiotic when the QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ranolazine?
MediHelp rates the interaction as moderate. Gemifloxacin and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine causes dose-related QT prolongation, and gemifloxacin can add to this effect. The combination may raise the risk of ventricular arrhythmia, especially in patients with structural heart disease.
How serious is the interaction between Gemifloxacin and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during the antibiotic course. Choose a non-QT-prolonging antibiotic when the QTc is already prolonged.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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