Drug interactions
Gentamicin + Hydrochlorothiazide-irbesartan
Severity: Moderate
Gentamicin and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause volume depletion and electrolyte loss, and angiotensin receptor blockers reduce renal perfusion pressure in volume-depleted patients. Together with gentamicin, which is directly nephrotoxic and ototoxic, this raises the risk of acute kidney injury and aminoglycoside accumulation. Electrolyte disturbances such as hypokalemia or hypomagnesemia may also occur.
What this interaction means in plain words
Gentamicin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive renal hemodynamic compromise from diuretic-induced volume depletion and ARB efferent arteriolar dilation, combined with direct aminoglycoside tubular toxicity.
What to do
Monitor serum creatinine, potassium and magnesium regularly, and check gentamicin levels with dose adjustment for renal function. Consider temporarily withholding the diuretic/ARB combination during acute illness or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Gentamicin and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause volume depletion and electrolyte loss, and angiotensin receptor blockers reduce renal perfusion pressure in volume-depleted patients. Together with gentamicin, which is directly nephrotoxic and ototoxic, this raises the risk of acute kidney injury and aminoglycoside accumulation. Electrolyte disturbances such as hypokalemia or hypomagnesemia may also occur.
How serious is the interaction between Gentamicin and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium regularly, and check gentamicin levels with dose adjustment for renal function. Consider temporarily withholding the diuretic/ARB combination during acute illness or volume depletion.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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