Drug interactions
Gentamicin + Hydrochlorothiazide
Severity: Moderate
Gentamicin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics cause potassium and magnesium loss and volume depletion, while gentamicin can cause renal electrolyte wasting and nephrotoxicity. Combined use can worsen electrolyte disturbances and may increase the risk of kidney injury.
What this interaction means in plain words
Gentamicin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium and magnesium wasting, with diuretic-related volume depletion increasing aminoglycoside nephrotoxicity.
What to do
Monitor serum potassium, magnesium, creatinine and gentamicin levels, and correct volume depletion and electrolyte deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Gentamicin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Gentamicin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics cause potassium and magnesium loss and volume depletion, while gentamicin can cause renal electrolyte wasting and nephrotoxicity. Combined use can worsen electrolyte disturbances and may increase the risk of kidney injury.
How serious is the interaction between Gentamicin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium, creatinine and gentamicin levels, and correct volume depletion and electrolyte deficits promptly.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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