Drug interactions
Gentamicin + Levoketoconazole
Severity: Minor
Gentamicin and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A P-glycoprotein effect on gentamicin is theoretical and has not been shown to be clinically significant, as gentamicin is eliminated by glomerular filtration. Levoketoconazole prolongs the QT interval and may cause hepatotoxicity, but this does not directly involve gentamicin.
What this interaction means in plain words
Gentamicin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gentamicin belongs to Anti Bacterial; Levoketoconazole belongs to Endocrine.
Why it happens
Theoretical P-glycoprotein inhibition; no established pharmacokinetic effect on gentamicin.
What to do
No dose change is needed. Continue standard gentamicin monitoring of levels and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Gentamicin with Levoketoconazole?
MediHelp rates the interaction as minor. Gentamicin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A P-glycoprotein effect on gentamicin is theoretical and has not been shown to be clinically significant, as gentamicin is eliminated by glomerular filtration. Levoketoconazole prolongs the QT interval and may cause hepatotoxicity, but this does not directly involve gentamicin.
How serious is the interaction between Gentamicin and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Continue standard gentamicin monitoring of levels and renal function.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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