Drug interactions
Gentamicin + Metolazone
Severity: Moderate
Gentamicin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone is a potent thiazide-like diuretic that causes marked potassium, magnesium and sodium loss and volume depletion. With gentamicin, electrolyte disturbances and nephrotoxicity risk increase.
What this interaction means in plain words
Gentamicin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Metolazone belongs to Cardiovascular.
Why it happens
Additive renal electrolyte wasting, with diuretic-induced volume depletion increasing aminoglycoside nephrotoxicity.
What to do
Monitor potassium, magnesium, creatinine and gentamicin levels, and replace electrolytes promptly. Avoid volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Metolazone
Frequently asked questions
Can I take Gentamicin with Metolazone?
MediHelp rates the interaction as moderate. Gentamicin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone is a potent thiazide-like diuretic that causes marked potassium, magnesium and sodium loss and volume depletion. With gentamicin, electrolyte disturbances and nephrotoxicity risk increase.
How serious is the interaction between Gentamicin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium, creatinine and gentamicin levels, and replace electrolytes promptly. Avoid volume depletion.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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