Drug interactions
Gepirone + Indacaterol-glycopyrronium
Severity: Moderate
Gepirone and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is associated with dose-related QT prolongation, and inhaled beta-agonists such as indacaterol can also lengthen the QTc interval, particularly when hypokalemia is present. Combined use may add to the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Gepirone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization (QT prolongation), with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and cardiac symptoms, and reconsider the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Gepirone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is associated with dose-related QT prolongation, and inhaled beta-agonists such as indacaterol can also lengthen the QTc interval, particularly when hypokalemia is present. Combined use may add to the risk of ventricular arrhythmias, especially in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Gepirone and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc and cardiac symptoms, and reconsider the combination if the QTc becomes markedly prolonged.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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