Drug interactions
Gepirone + Perphenazine
Severity: Major
Gepirone and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone can prolong the QT interval and has serotonergic activity, and perphenazine also affects QT and serotonin receptors. The combination raises risk of arrhythmia and, theoretically, serotonin syndrome.
What this interaction means in plain words
Gepirone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gepirone belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and overlapping serotonergic effects; gepirone is a CYP3A4 substrate and perphenazine is not a significant inhibitor.
What to do
Obtain baseline and follow-up ECGs and correct electrolytes. Monitor for serotonin syndrome and consider an alternative if QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Perphenazine?
MediHelp rates the interaction as major. Gepirone and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone can prolong the QT interval and has serotonergic activity, and perphenazine also affects QT and serotonin receptors. The combination raises risk of arrhythmia and, theoretically, serotonin syndrome.
How serious is the interaction between Gepirone and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and correct electrolytes. Monitor for serotonin syndrome and consider an alternative if QTc rises.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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