Drug interactions
Gepirone + Solifenacin
Severity: Moderate
Gepirone and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with electrolyte disturbance, bradycardia or heart disease. Gepirone also carries a QT warning in its labeling.
What this interaction means in plain words
Gepirone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarisation; gepirone is also a CYP3A4 substrate.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG, and avoid the combination in patients with congenital long QT or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Solifenacin?
MediHelp rates the interaction as moderate. Gepirone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is higher with electrolyte disturbance, bradycardia or heart disease. Gepirone also carries a QT warning in its labeling.
How serious is the interaction between Gepirone and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the ECG, and avoid the combination in patients with congenital long QT or other risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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