Drug interactions
Gilteritinib + Goserelin
Severity: Moderate
Gilteritinib and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is labeled for QT prolongation, and goserelin may add to the effect. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Gilteritinib and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Goserelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and repeat it during the first month of gilteritinib. Correct electrolytes and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Goserelin?
MediHelp rates the interaction as moderate. Gilteritinib and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib is labeled for QT prolongation, and goserelin may add to the effect. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Gilteritinib and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it during the first month of gilteritinib. Correct electrolytes and reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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