Drug interactions
Gilteritinib + Indacaterol
Severity: Moderate
Gilteritinib and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and long-acting beta-agonists may add to this effect and lower potassium. The combination may increase the risk of torsades de pointes, particularly in patients with electrolyte abnormalities.
What this interaction means in plain words
Gilteritinib and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium in the normal range. Reduce or interrupt the QT-prolonging drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Indacaterol?
MediHelp rates the interaction as moderate. Gilteritinib and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and long-acting beta-agonists may add to this effect and lower potassium. The combination may increase the risk of torsades de pointes, particularly in patients with electrolyte abnormalities.
How serious is the interaction between Gilteritinib and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium in the normal range. Reduce or interrupt the QT-prolonging drug if QTc becomes markedly prolonged.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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