Drug interactions
Gilteritinib + Mirtazapine
Severity: Moderate
Gilteritinib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval and mirtazapine has been linked to QT prolongation in some circumstances. Combined use may increase the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Gilteritinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QTc interval prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium abnormalities. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Mirtazapine?
MediHelp rates the interaction as moderate. Gilteritinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib can prolong the QT interval and mirtazapine has been linked to QT prolongation in some circumstances. Combined use may increase the risk of ventricular arrhythmias, particularly in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Gilteritinib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and correct potassium and magnesium abnormalities. Reduce or interrupt gilteritinib if QTc becomes markedly prolonged.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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