Drug interactions
Gilteritinib + Tiotropium-olodaterol
Severity: Moderate
Gilteritinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval and olodaterol may add to arrhythmia risk through hypokalemia and increased heart rate. The combination raises the possibility of torsades de pointes, especially in patients with electrolyte disturbances.
What this interaction means in plain words
Gilteritinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia and sympathetic stimulation.
What to do
Perform ECG monitoring at baseline and during therapy, and correct potassium and magnesium abnormalities. Reassess the need for olodaterol if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gilteritinib and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Gilteritinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval and olodaterol may add to arrhythmia risk through hypokalemia and increased heart rate. The combination raises the possibility of torsades de pointes, especially in patients with electrolyte disturbances.
How serious is the interaction between Gilteritinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and during therapy, and correct potassium and magnesium abnormalities. Reassess the need for olodaterol if QTc rises significantly.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
