Drug interactions
Givosiran + Imipramine
Severity: Moderate
Givosiran and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to sensitive CYP2D6 substrates such as imipramine. This may increase tricyclic adverse effects, including cardiac conduction effects and anticholinergic symptoms.
What this interaction means in plain words
Givosiran and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing imipramine metabolism.
What to do
Consider reducing the imipramine dose per labeling and monitor for tricyclic toxicity. Check ECG and imipramine concentrations if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Imipramine?
MediHelp rates the interaction as moderate. Givosiran and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to sensitive CYP2D6 substrates such as imipramine. This may increase tricyclic adverse effects, including cardiac conduction effects and anticholinergic symptoms.
How serious is the interaction between Givosiran and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the imipramine dose per labeling and monitor for tricyclic toxicity. Check ECG and imipramine concentrations if available.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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