Drug interactions
Givosiran + Lidocaine
Severity: Minor
Givosiran and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP1A2 activity, and lidocaine is partly cleared by CYP1A2 (with CYP3A4 as the main route). Lidocaine exposure could increase modestly, which matters mainly with systemic or prolonged infusions.
What this interaction means in plain words
Givosiran and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Lidocaine belongs to Cardiovascular.
Why it happens
Givosiran-related reduction in CYP1A2 activity decreases lidocaine metabolism.
What to do
No adjustment for local use; for systemic lidocaine, monitor for toxicity symptoms and consider dose reduction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Lidocaine?
MediHelp rates the interaction as minor. Givosiran and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran reduces CYP1A2 activity, and lidocaine is partly cleared by CYP1A2 (with CYP3A4 as the main route). Lidocaine exposure could increase modestly, which matters mainly with systemic or prolonged infusions.
How serious is the interaction between Givosiran and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment for local use; for systemic lidocaine, monitor for toxicity symptoms and consider dose reduction.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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