Drug interactions
Givosiran + Nortriptyline
Severity: Moderate
Givosiran and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to drugs cleared by CYP2D6. Nortriptyline is a CYP2D6 substrate with a narrow therapeutic margin, so toxicity such as sedation, anticholinergic effects and arrhythmias may occur.
What this interaction means in plain words
Givosiran and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Nortriptyline belongs to Central Nervous System.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing nortriptyline metabolism.
What to do
Consider reducing the nortriptyline dose, guided by response and plasma levels. Monitor for adverse effects and ECG changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Givosiran and Nortriptyline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Nortriptyline?
MediHelp rates the interaction as moderate. Givosiran and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to drugs cleared by CYP2D6. Nortriptyline is a CYP2D6 substrate with a narrow therapeutic margin, so toxicity such as sedation, anticholinergic effects and arrhythmias may occur.
How serious is the interaction between Givosiran and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the nortriptyline dose, guided by response and plasma levels. Monitor for adverse effects and ECG changes.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
