Drug interactions
Givosiran + Paroxetine
Severity: Moderate
Givosiran and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, which may raise exposure to sensitive CYP2D6 substrates. Paroxetine is metabolized by CYP2D6 and itself inhibits it, so levels may rise and adverse effects may increase.
What this interaction means in plain words
Givosiran and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Paroxetine belongs to Central Nervous System.
Why it happens
Givosiran-associated reduction in CYP2D6 activity decreases paroxetine clearance.
What to do
Monitor for paroxetine adverse effects such as nausea, sedation, and serotonergic symptoms, and reduce the dose if they occur. Follow labeling guidance on CYP2D6 substrate dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Paroxetine?
MediHelp rates the interaction as moderate. Givosiran and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, which may raise exposure to sensitive CYP2D6 substrates. Paroxetine is metabolized by CYP2D6 and itself inhibits it, so levels may rise and adverse effects may increase.
How serious is the interaction between Givosiran and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paroxetine adverse effects such as nausea, sedation, and serotonergic symptoms, and reduce the dose if they occur. Follow labeling guidance on CYP2D6 substrate dose reduction.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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