Drug interactions
Givosiran + Pirfenidone
Severity: Moderate
Givosiran and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity and may raise concentrations of CYP1A2 substrates such as pirfenidone. Higher pirfenidone exposure increases the risk of nausea, rash, photosensitivity and liver enzyme elevation.
What this interaction means in plain words
Givosiran and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Pirfenidone belongs to Miscellaneous.
Why it happens
Givosiran decreases CYP1A2 activity, reducing pirfenidone clearance.
What to do
Monitor for pirfenidone adverse effects and liver enzymes, and reduce the pirfenidone dose if tolerability problems arise. Consider an alternative if it cannot be managed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Pirfenidone?
MediHelp rates the interaction as moderate. Givosiran and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity and may raise concentrations of CYP1A2 substrates such as pirfenidone. Higher pirfenidone exposure increases the risk of nausea, rash, photosensitivity and liver enzyme elevation.
How serious is the interaction between Givosiran and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and liver enzymes, and reduce the pirfenidone dose if tolerability problems arise. Consider an alternative if it cannot be managed.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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