Drug interactions
Givosiran + Rasagiline
Severity: Moderate
Givosiran and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and rasagiline is mainly cleared by CYP1A2. Exposure to rasagiline may therefore rise, increasing its adverse effects.
What this interaction means in plain words
Givosiran and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.
Why it happens
Givosiran inhibits CYP1A2, reducing rasagiline metabolism.
What to do
Lower the rasagiline dose as per labeling if coadministration is necessary, and monitor for increased adverse effects such as dizziness and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Rasagiline?
MediHelp rates the interaction as moderate. Givosiran and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and rasagiline is mainly cleared by CYP1A2. Exposure to rasagiline may therefore rise, increasing its adverse effects.
How serious is the interaction between Givosiran and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the rasagiline dose as per labeling if coadministration is necessary, and monitor for increased adverse effects such as dizziness and hypotension.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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