Drug interactions
Givosiran + Ropinirole
Severity: Moderate
Givosiran and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP1A2 activity and can increase exposure to CYP1A2 substrates. Ropinirole is metabolized mainly by CYP1A2, so levels may rise, causing nausea, dizziness, somnolence, hypotension or hallucinations.
What this interaction means in plain words
Givosiran and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Ropinirole belongs to Central Nervous System.
Why it happens
Givosiran inhibits CYP1A2, decreasing the metabolic clearance of ropinirole.
What to do
Monitor for ropinirole adverse effects and reduce the ropinirole dose if they appear. Titrate to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Ropinirole?
MediHelp rates the interaction as moderate. Givosiran and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran reduces CYP1A2 activity and can increase exposure to CYP1A2 substrates. Ropinirole is metabolized mainly by CYP1A2, so levels may rise, causing nausea, dizziness, somnolence, hypotension or hallucinations.
How serious is the interaction between Givosiran and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ropinirole adverse effects and reduce the ropinirole dose if they appear. Titrate to clinical response.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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