Drug interactions
Givosiran + Timolol
Severity: Moderate
Givosiran and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6 and may increase exposure to timolol. This may enhance beta-blockade, causing bradycardia or hypotension.
What this interaction means in plain words
Givosiran and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Timolol belongs to Cardiovascular.
Why it happens
Givosiran inhibits CYP2D6-mediated timolol metabolism.
What to do
Monitor heart rate and blood pressure and lower the timolol dose if needed. Consider an alternative beta-blocker not dependent on CYP2D6.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Timolol?
MediHelp rates the interaction as moderate. Givosiran and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can moderately inhibit CYP2D6 and may increase exposure to timolol. This may enhance beta-blockade, causing bradycardia or hypotension.
How serious is the interaction between Givosiran and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and lower the timolol dose if needed. Consider an alternative beta-blocker not dependent on CYP2D6.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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