Drug interactions
Givosiran + Tolterodine
Severity: Moderate
Givosiran and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can moderately inhibit CYP2D6 activity, which may increase tolterodine exposure. The clinical effect is probably modest because CYP3A4 provides an alternative route.
What this interaction means in plain words
Givosiran and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Givosiran reduces CYP2D6 activity, slowing tolterodine metabolism.
What to do
Monitor for anticholinergic effects and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Tolterodine?
MediHelp rates the interaction as moderate. Givosiran and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can moderately inhibit CYP2D6 activity, which may increase tolterodine exposure. The clinical effect is probably modest because CYP3A4 provides an alternative route.
How serious is the interaction between Givosiran and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the tolterodine dose if they occur.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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