Drug interactions
Glimepiride + Posaconazole
Severity: Moderate
Glimepiride and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise glimepiride concentrations by inhibiting its CYP2C9-mediated and possibly CYP3A4-mediated clearance. This can lead to enhanced glucose lowering and hypoglycemia.
What this interaction means in plain words
Glimepiride and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of hepatic metabolism of the sulfonylurea by posaconazole.
What to do
Monitor blood glucose closely when starting or stopping posaconazole and reduce the glimepiride dose if hypoglycemia occurs. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Posaconazole?
MediHelp rates the interaction as moderate. Glimepiride and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise glimepiride concentrations by inhibiting its CYP2C9-mediated and possibly CYP3A4-mediated clearance. This can lead to enhanced glucose lowering and hypoglycemia.
How serious is the interaction between Glimepiride and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping posaconazole and reduce the glimepiride dose if hypoglycemia occurs. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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